Background Inhaled anesthetics as kinds of commonly used anesthesia drugs, are widely used in all kinds of surgeries, recent research date ind-icate that inhaled anesthetics may have a protective effects on the immune response. Objective To summarize the advance of inhaled anesthetics on the immunoregulatory effects and mechanisms. Content the immunoregulatory effects and mechanisms. Content We elaborate the immunoregulatory effects of inhaled anesthetics on acute lung injury, sepsis, ischemia-reperfusion injury, tumor and allergy. Trend Further study on the immuno-regulatory effects and mechanisms of inhaled anesthetics can offer an basis for clinical anesthesia medication and future immunotherapy.