Ｏｂｊｅｃｔｉｖｅ　To investigate the effect of dexmedetomidine（Dex） on the hemodynamic response to the induction of general anesthesia and tracheal intubation with pulse indicated continue cardiac output （PiCCO）.　Methods　A total of twenty four patients scheduled for orthotopic liver transplantation were enrolled in this study. According to random number table， they were assigned to Dex group （group DP, an initial dose of 0.5 μg/kg for 10 min， followed by a continuous infusion of 0.5 μg·kg-1·h-1， n=12） and control group （group NS， an initial dose of the same amount of 0.9% sodium chloride， n=12）. Anesthesia was induced with propofol and remifentanil using a target-controlled infusion（TCI） system. The initial target propofol and remifentanil effective concentration were 3.0 mg/L and 3.0 μg/L respectively， followed by intravenous injection with 0.15 mg/kg cisatracurium. Intubation was carried out until the TCI system reached the effective concentration. Mean arterial pressure （MAP）， heart rate（HR）， pulse indicator continuous cardiac index （PCCI）， systemic vascular resistance index （SVRI）， global ejection fraction （GEF）， central venous pressure （CVP）， extravascular lung water （EVLW） ， Narcotrend number （NT） were recorded at time points of pre-Dex（T0）， post-Dex（T1）， TCI system reached the effective concentration（T2）， intubation（T3）， 1 min after intubation（T4）， 3 min after intubation（T5）， 5 min after intubation（T6）.　Results　Compared with T0 and group NS， SVRI was increased significantly at T1［2 012±627） dyne·s·cm-5·m-2］ （P<0.05）. EVLW， HR and NT were significantly decreased at T1（P<0.05） in group DP. Compared with T0 and T1， PCCI was sharply decreased at T2 in group NS and group DP， and compared with group NS， PCCI was significantly higher at T2 in group DP ［（2.64±0.55） L·min-1·m-2 vs （3.24±0.47） L·min-1·m-2］（P<0.01）. In group DP， PCCI with an upward tendency from T3 to T6 was significantly higher than group NS at T5 and T6 respectively（P<0.05）. GEF at from T2［（28.5±2.8）% vs （20.1±3.8）%］　to T6 ［（28.2±3.2） % vs （19.0±3.5）%］　in group DP was obviously higher than NS（P<0.05）. Compared with T0 and T1， MAP，GEF，PCCI and SVRI in group NS at T2 were decreased significantly（P<0.05）， then increased obviously at T3， and fell at T4-T5， till T6 reached to the level of T2. The number of EVLW was progressively ascending in group NS， and were significantly higher than group DP at T1［（424±80） ml vs （345±68） ml］-T6［（445±85） ml vs （340±66） ml］（P<0.05）.　Conclusions　For the patients undergoing liver transplantation， Dex administration during anesthetic induction is useful， because it not only increased the MAP， maintained the GEF and PCCI， but also decreased the EVLW.