国际麻醉学与复苏杂志   2016, Issue (2): 8-8
    
胃泌素释放肽在炎性疾病中的作用
李金宝, 阮林星, 郭龙, 蒋李1()
1.长海医院
Roles of gastrin-releasing peptide in inflammatory diseases
 全文:
摘要：

背景　胃泌素释放肽（gastrin-releasing peptide， GRP）是一种神经肽，属于铃蟾肽类（bombesin， BB），表达于多种组织（胃肠系统、呼吸系统、神经系统、内分泌腺以及骨骼肌等）。胃泌素释放肽受体（gastrin-releasing peptide receptor， GRPR）属于G蛋白耦联受体（G protein coupled receptors， GPCRs）。近年来，GRP在炎症性疾病中的作用备受关注，研究显示RC-3095作为GRPR特异性拮抗剂具有抗炎作用。　目的　探讨GRP在炎性疾病中的作用及其研究现状。　内容　主要从脓毒症、关节炎、胃肠炎、眼葡萄膜炎等炎性疾病着手，对 GRP在炎症疾病中的作用进行归纳总结。　趋向　GRP-GRPR将有可能成为炎性疾病的潜在治疗靶点，并有望实现从基础研究到临床应用的转化。
关键词： 胃泌素释放肽；　RC-3095；　炎症；　中性白细胞；　铃蟾肽
Abstract:

Background　Gastrin-releasing peptide (GRP), a neuropeptide, belongs to the bombesin (BB) and is expressed in various organs (such as gastrointestinal system, respiratory system, nervous system, endocrine gland and skeletal muscles). Gastrin-releasing peptide receptors (GRPR) is a kind of G protein coupled receptors (GPCRs). In recent years, more and more studies have focused on potential roles of GRP in inflammatory diseases. RC-3095, as a specific GRPR antagonist, has been found to have anti-inflammatory properties.　Objective　To investigate the potential roles and research situation of GRP-GRPR in inflammatory diseases.　Content　Mainly focusing on reviewing sepsis, arthritis, gastroenteritis, and uveitis, we summarized the roles of GRP-GRPR in inflammatory diseases.　Trend　In conclusion, GRP and its receptor is a potential therapeutic target in inflammatory diseases as well as the possible transformation from preclinical findings to clinical application.
Key words: Gastrin-releasing peptide;　RC-3095;　Inflammation;　Neutrophil;　Bombesin