Abstract: Background Hepatic ischemia/reperfusion injury(HI/RI) is common pathophysiological phenomenon in liver surgery and liver transplantation. HI/RI is the most important factor of liver dysfunction and non-function of graft after hepatic surgery.Although it has been indicated that limb ischemia preconditioning(LIPC) can reduce HI/RI, its mechanism is not completely elucidated. Objective This review summarizes the potential mechanism of LIPC reducing HI/RI, which provides new ideas of preventing HI/RI in clinic. Content This review describes the potential mechanism of HI/RI and LIPC reducing HI/RI. Trend LIPC as a way of preventing HI/RI has significant clinical value.
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