Background Some of the earliest detailed descriptions of biophysical properties of low voltage-activated (LVA) or transient (T) type Calcium channels were done using in vitro preparation of primary sensory or dorsal root ganglion (DRG) neurons that are known for their functional role in processing pain signals. However, in spite of these early discoveries, T-type calcium channels were not implicated in sensory transmission in general and pain processing (nociception) in particular until recently. Objective peripheral T-type Calcium channels in boosting nociceptive transmission in a variety of experimental pain models. Content T-type calcium channels in peripheral sensory neurons play important role under physiological conditions (e.g. acute nociceptive pain) and to pain processing under pathological conditions. Trend peripheral T-type Calcium channels in nociception and the value of these channels as cellular targets for potential drug developments.