Objective To compare the efficacy of femoral nerve block(FNB) with epidural and patient-controlled analgesia(PCA) for postoperative analgesia after total knee arthroplasty. Methods We searched the PubMed, OVID, EMBASE, Cochrane library, for all randomized controlled trials（RCTs）about the efficacy of FNB versus epidural or PCA .The quality of the studies was evaluated by the method recommended by Cochrane Collaboration. Meta-analysis was conducted using the Cochrane Collaboration’s RevMan 5.2 software. Results We identified 14 RCTs finally, which compared FNB with epidural or PCA. In these studies, there were 1,157 patients in total, of whom 616 patients received femoral nerve block, 380 patients received PCA and 161 patients received epidural analgesia. FNB was found to reduce morphine consumption at 24h (WMD=-17.93，95%CI -27.38～-8.49) and at 48h (WMD=-25.70，95%CI -41.67～-9.74),VAS scores with activity at 48h(WMD=-1.99,95%CI -3.14～-0.85) when it is compared with PCA. In addition, FNB was found to reduce the incidence of postoperative nausea and vomiting(OR=0.31，95%CI 0.22～0.44), retention of urine(OR=0.24，95%CI 0.13～0.43) and dizziness(OR=0.27，95%CI 0.14～0.52). Conclusion Compared with PCA or epidural analgesia, FNB may be a better alternative analgesia technology for the patients who underwent TKA.