Abstract: Objective To discuss the effects of multimodal analgesia combined with flurbiprofen and compatibility of dexamethasone on postoperative recovery after gynecological laparoscopic day-case surgery. Method 90 cases of patients undergoing elective gynecological laparoscopic day-case surgery were randomly divided into 3 groups，during anaesthetic induction:group A and B was given 0.1mg/kg dexamethasone by intravenous injection, but group C was given 2 ml normal saline by intravenous injection; after anaesthetic induction: group A and C was given 1mg/kg flurbiprofen plus 0.9% NaCl 100 ml by intravenous injection slowly, but group B was given normal saline by intravenous injection slowly. All groups were given 8 mg ondansetron by intravenous injection at the end of surgery. The postoperative pain of the patients at 0、2、4、6 and 8h after surgery in 3 groups，was evaluated and recorded using a visual analogue scale（VAS）and bruggrmann comfort scale（BCS）.Other related adverse effects were also noted. Results VAS scores at 0, 2h after surgery was significantly lower in group A than in group C（P＜0.05）, group C was significantly lower than group B（P＜0.05）; VAS scores at 4h after surgery was significantly lower in group A and C than in group B（P＜0.05）; BCS scores at 0, 2h after surgery was significantly higher in group A than in group C（P＜0.05）, group C was significantly higher than group B（P＜0.05）; BCS scores at 4h after surgery was significantly higher in group A and C than in group B （P＜0.05）. Compared to group A（0%） and C（10%）, the incidence of using postoperative analgesic drugs was significantly higher in group B（23%）（P＜0.05）; the incidence of postoperative nausea and vomiting （PONV）were significantly higher in group B（27%）and C（30%） than that in group A（3%）（P＜0.05）; the incidence of extending stay time were significantly higher in group B（23%）and C（20%）than that in group A（3%） （P＜0.05）.Conclusion Multimodal analgesia combined with flurbiprofen and compatibility of dexamethasone can significantly improve the comfort degree of patients after gynecologic laparoscopic day-csae surgery.