Abstract: Objective To investigate the effect and safety of hydromorphone combined with propofol for patients underwent colonoscopy. Methods Sixty outpatients were randomly divided into group A and group B with 30 patients in each group, of ASA physical statusⅠor Ⅱ, according to random number tables. Anesthesia was induced with hydromorphone 0.5 mg and propofol for patients in group A , while patients in group B were induced with normal saline and propofol. The SBP, HR and SpO2 were recorded before examination(T0), inserting colonoscopy simultaneously(T1), reaching ileocecum junction(T2), and at the end of examination(T3). Propofol consumption, side effects, post-operative VAS scores, recovery time, examination time and discharge time were recorded accordingly. Results The anesthesia effect in group A was better than that in group B (P<0.05). The HR, SBP and SpO2 in two groups at T1 and T2 were lower than those at T0 (P<0.05). Both of the SBP and HR in group B at T1 and T2 were significantly lower than those in group A(P<0.05). The propofol consumption [(103±14) mg] in group A was significantly less than that in group B [(170±22) mg] (P<0.05). The VAS scores (1.2±0.6) in group A was lower than that in group B (3.0±0.6)(P<0.05). The movement response occurred in 5 and 18 patients in group A and B (P<0.05), respectively. Conclusions Hydromorphone combined with propofol can be safely used for patients underwent painless colonoscopy and reduce propofol consumption.
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