【摘要】 目的 观察吸入七氟烷对糖尿病小鼠认知功能的影响。 方法 健康昆明小鼠40只，采用随机数字法，将其随机分为4组（n=10）：对照组（C组）吸入空气，糖尿病组（DM组）吸入空气，七氟烷组（S组）吸入1.5%七氟烷6小时，七氟烷糖尿病组（DM+S组）吸入1.5%七氟烷6小时。在24小时后，分别用跳台法，避暗法记录遗忘小鼠错误次数（error times，ETs）、跳台潜伏期（step down latancy，SDL）和步入潜伏期（step through latancy，STL）。 结果 与C组比较，DM组、S组、DM+S组跳台潜伏期和步入潜伏期均缩短、错误次数增加（P<0.05）。与DM+S组比较，DM组、S组的跳台潜伏期和步入潜伏期均缩短、错误次数均增加（P<0.05）。 结论 吸入七氟烷对糖尿病小鼠短期内的认知功能有影响，加重糖尿病对认知功能的损害。
[Abstract]: Objective To investigate the effects of sevoflurane on cognitive performance in diabetic mice. Methods Healthy mice were randomly divided into four groups (n=10 each): contrcl group（group C）;groupdiabetic mellitus group（group DM）; sevoflurane group (group S) diabetic mellitus and sevofurane group(group DM+S). goup C and group DM inhaled air for 6h; group S and group DM+S inhaled 1.5% sevoflurane for 6 h. After 24 h, the error times(ETs),step down latancy(SDL) and step through latancy(STL) were observed and recoded in the step-down test and step-through test. Results Compared with group C of group DM , group S and group DM+S decreased in SDL and STL（P < 0.05） ,increased in ETs（P < 0.05）. Compared with group DM+S, both group DM and group S decreased in SDL and STL(P<0.05),increased in ETs（P < 0.05）. Conclusions: Sevoflurane has a influence on the shortern memory in diabetic mice.
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