国际麻醉学与复苏杂志   2016, Issue (7): 8-8
    
葡萄糖转运蛋白-1与肺动脉高压相关性的研究进展
孙青, 马正良, 李冰冰1()
1.南京鼓楼医院
Research progress of GLUT-1 and pulmonary hypertension
 全文:
摘要：

背景 肺动脉高压（pulmonary arterial hypertension，PAH）是一种常见的全身性疾病。研究发现肺动脉高压患者损伤部位的肺动脉平滑肌细胞伴有能量代谢异常，葡萄糖转运蛋白（GLUT-1）异常高表达。目的 探讨GLUT-1在PAH中的研究进展，为治疗PAH提供新的治疗策略。内容 介绍GLUT-1的特性，探讨其在PAH疾病中上调的机制。 趋向 GLUT-1可能成为治疗PAH的新靶点，为PAH的治疗提供新的方向。
关键词： 肺动脉高压 ；葡萄糖转运蛋白-1
Abstract:

Backgroud Pulmonary arterial hypertension(PAH) is a common systemic disease. The study found the site of injury in patients with pulmonary hypertension associated with pulmonary vascular smooth muscle cell energy metabolism, glucose transporter (GLUT-1) abnormally high expression. Objective the aim of this review is to discuss the role of GLUT-1 in PAH, provide new therapeutic strategies for the treatment of PAH. Content At first,the characteristics of GLUT-1 were introduced.Secondly, we explored the mechanism of disease increases in PAH.Trend GLUT-1 may be a new target for the treatment of PAH, providing new directions for the treatment of PAH.
Key words: Pulmonary arterial hypertension; GLUT-1