（Background）Gap junction, which mediates intercellular material exchange and information communication, is consists of connexin family embedded in the cell surface. Excepting consisting of gap junction, connexin also constitutes a channel which directly access the cell and the internal environment，named hemichannel. Hemichannel mediates the exchange of the intracellular and extracellular ions, second messengers and intracellular metabolites, which plays an indispensable role in life activities. （Objective）；Classified, summarized and prospected Hemichannel function and its application （Content）this paper focuses on research progress on the roles of hemichannel in pathophysiological conditions and related diseases about hemichannel. （Trend）the research of hemichannel is still in its infancy, There are not many reports about hemichannel recently. for the further Reveal would contributes to understanding of the pathogenesis of related diseases and provide theoretical basis for preventive treatment.