Ｏｂｊｅｃｔｉｖｅ　To investigate the sevoflurane-sparing degree after dexmedetomidine(Dex) in patients with gynecological laparoscopy.　Methods　Forty ASA physical status Ⅰ or Ⅱ patients, aged 18-59 y, BMI 18.5-24.0 kg/m2, undergoing elective gynecological laparoscopy under general anesthesia were randomly divided into 2 groups (n=20) using a random number table: control group (group C) and Dex group(group D). Consider the stability of 10 min BP as the basic level after entering the operating room. Sevoflurane was inhaled after induction for anesthesia maitenance and adjusted the inspired concentration to maintain BIS values 40-60 within 10 min of laryngeal mask placement to the end of the surgery. Dex 1.0 μg/kg was infused intravenously over 10 min starting form 15 min before anesthesia induction, followed by 0.4 μg·kg-1·h-1 continuous infusion to about 15 min before the end of the surgery in group D whereas the same amount of normal saline was infused in an identical sequence in group C. Discontinue sevoflurane inhalation at the end of the operation. Record end-tidal concentration of sevoflurane(CETsevo) immediately after the incision(T1), pneumoperitoneum(T2), 10 min after pneumoperitoneum(T3) and laparoscopic procedure completed(T4). Record the masses of sevoflurane evaporation can immediately before the incision and the end of the surgery, and calculate sevoflurane consumption per unit of time. Record the time of the anesthesia, surgery, pneumoperitoneum, recovery and laryngeal mask airway removal. Record the incidence of postoperative agitation and adverse cardiovascular events. Postoperative follow-up to record whether the intraoperative awareness occurred or not.　Results　Compared with group C, CETsevo at T1-T4, sevoflurane consumption per unit of time, the time of recovery, the time of laryngeal mask airway removal and the incidence of postoperative agitation reduced(P<0.05 or P<0.01) in group D. No adverse cardiovascular event or intraoperative awareness occurred in either group. Compared with group C, CETsevo respectively reduced by 20.6%, 28.1%, 26.1% and 25.0% at T1-T4 in group D(P<0.05). The sevoflurane consumption per unit of time in group D was spared about 29.0% compared with group C(P<0.01).　Conclusions　Dex can reduce the CETsevo by about 20.6%-28.1%, sparing 29.0% of sevoflurane in patients with gynecological laparoscopy, thus shortening the time of recovery and unplug the laryngeal mask airway, decreasing the incidence of postoperative agitation.