Ｏｂｊｅｃｔｉｖｅ　To investigate the change of liver function and blood coagulation in patients with traumatic shock and the therapeutic effect of ulinastatin(UTI).　Methods　Collect 128 patients' datawho were diagnosed with traumatic shock and admitted in ICU in Tangdu hospital from January 2013 to March 2015, according to the injury severity score and whether application of UTI treatment, they were divided into six groups: mild, moderate and severe shock of UTI treatment group， mild, moderate and severe shock of routine antishock treatment group. Related laboratory parameters were collected to evaluate the effect of UTI on patients, including acute physiology and chionic health evaluation scoring system(APACHE Ⅱ) score upon patients'admission, total length of stay in hospital and ICU, mortality, levels of AST, ALT, blood platelet(PLT), prothrombin time(PT), activated partial thromboplastin time(APTT), plasma fibrinogen(Fib), fibrin(agen) degradation products(FDP), D-dimer(D-D).　Results　① In mild and moderate traumatic shock group,the total hospital staying time were（11.0±3.0）, (14.0±4.0 ) d in UTI treatment group, it were reduced by 26.7%, 30% respectively, compared with the routine antishock treatment group;and the ICU staying time were (6.2±1.8), (9.5±2.0) d, it were reduced by 42.1%, 33.6% respectively(P< 0.05). ② In mild, moderate and severe traumatic shock group, the AST were (46±19), (68±63), (258±133) U/L in the 7th days in UTI treatment group, it were reduced by 21.1%, 29.4%, 32.1% respectively, compared with the routine antishock treatment group; and the ALT were (58±16), (68±25), (199±53) U/L，it were reduced by 13.9%, 41.3%, 41.3% respectively(P<0.05). ③ In mild and moderate traumatic shock group, the FDP were (20.6±3.2), (32.0±8.5) mg/L, in the 7th days in UTI treatment group, it were reduced by 42.0%, 34.0% respectively, compared with the routine antishock treatment group. The D-D were (2.2±0.5), (4.0±0.9) mg/L, it were reduced by 35.76%, 24.5% respectively. The PT were (10.5±1.2), (11.2±1.2) s, it were reduced by 7.1%, 11.4% respectively. The APTT were (26.5±2.8), (34.2±3.1) s, it were reduced by 15.6%, 9.6% respectively. The Fib were (4.3±0.4), (4.1±0.4) g/L, it were increased by 19.3%, 22.1% respectively. PLT were(200±24)×109/L, (186±28)×109/L, it were increased by 9.6%, 40.0% respectively(P<0.05).　Conclusions　In patients with mild and moderate shock, UTI can improve liver function and blood coagulation function, reduce the total staying time in hospital and ICU, and improve prognosis. While in severe traumatic shock group, UTI did not show any obvious therapeutic effect.