背景 星形胶质细胞是脑内重要的胶质细胞，对神经元的能量代谢、信号转导、电活动等方面都有重要的支持作用。脑缺血后星形胶质细胞能量代谢的变化，影响了神经元的存活和整个大脑的功能恢复。 目的 以星形胶质细胞能量代谢改变为切入点，探索治疗脑缺血疾病的新策略。 内容 从星形胶质细胞正常的能量代谢、缺血后星形胶质细胞能量代谢的改变、缺血引起能量代谢改变的可能机制以及临床意义4个方面进行综述。 趋向 为寻找基于星形胶质细胞的缺血早期干预和治疗措施提供新思路。
Background Astrocytes were important glial cells which played an crucial role in the energetic metabolism, signal transduction and electrical activities in neurons. The energetic metabolism of astrocytes after cerebral ischemia affected neurons' survival and brain function. Objective To explore a new treatment strategy for cerebral ischemia on the basis of energetic metabolism of astrocytes. Content This review article would focus on how energetic metabolism of astrocytes would change after ischemia and its possible mechanism and clinical significance. Trend Provide a new thought on the treatment of early cerebral ischemia.
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