Ｏｂｊｅｃｔｉｖｅ　To investigate the rational dose of sufentanil combined with etomidate during induction of anesthesia in elderly patients with laryngeal mask.　Methods　Sixty patients of ASAⅠ，Ⅱaged 65-80 years old and undergoing selective surgery were randomly divided into 3 groups(n=20): groupⅠ， group Ⅱ and group Ⅲ. GroupⅠ, group Ⅱ and group Ⅲwere given sufentanil 0.3, 0.4 μg/kg and 0.5 μg/kg respectively with the same dose of etomidate. SBP, DBP, MAP, HR, cardiac output(CO) and stroke volume variation (SVV) were recorded before anesthesia (T0), 3 min after injection of sufentanil(T1), and at 0 min(T2), 1 min(T3), 3 min(T4), 5 min(T5) after laryngeal mask airway insertion. The times of vasoactive drugs' use were also recorded.　Results　Compared with T0， the SBP, DBP, MAP of the 3 groups all decreased after induction (P<0.05), it was more obvious in group Ⅲ than group Ⅰ(P<0.05). The HR of group Ⅲ slowed at T4 and T5 than T1(P<0.05). The CO of group Ⅰ and Ⅱ after induction was no statistical difference compared with T0(P＞0. 05). CO in group Ⅲ decreased at T3 and T4. The CO of group Ⅲ at T3 and T4 was 3.5 L/min. And CO of group Ⅰ at the same time was 3.7 L/min and 3.8 L/min. There was no significant difference between groupⅠ and group Ⅱ(P＞0. 05). The times of vasoactive drugs' use were 1, 2 and 6 respectively. There was a significant difference in the times of vasoactive drugs' use among the 3 groups (P<0.05).　Conclusions　Among the elderly patients with laryngeal mask airway, 0.3 μg/kg or 0.4 μg/kg sufentanil administrated during induction can inhibit the response of laryngeal mask airway insertion; with minimal respiratory and circulatory depression．