【Abstact】 Background：In the conventional idea, lactic acid is a waste of glucose in anaerobic metabolism. However, lactic acid has been shown that it can be used as an energy material in the body. The existence of a large number of lactate shuttle phenomenon can guarantee the body,s metabolism between tissue and cell. Objective: This article will combine domestic with foreign related research to elaborate the myocardial protection of the lactate shuttle mechanism. Content: Lactic acid is the product of glycolysis of glucose. The phenomenon of lactate shuttle is that lactate shuttle can supply energy for each other in different tissues and cells of the body.The lactate transporter (MCT),adhesion molecule(CD147) and lactate hydrogenase (LDH).The protection of myocardium in ischemia-reperfusion injury is because that lactate shuttle can opotimize energy metabolism and influence the concentration calcium ions. Tend: The study found that lactic acid has important significance in energy metabolism and the lactate shuttle can supply the energy metabolic pathways for the body. However,the study of the regulation mechanism of lactate shuttle for myocardium ischemia-reperfusion injury is less.