【Abstract】Objective Observe the clinical effect of Ketorolac in the reduction of postoperative annoyance in bilateral endoscopic thoracic sympathectomy. Methods 60 cases of selective bilateral endoscopic thoracic sympathectomy, classified ASA I〜II, from March 2014 to August 2015, are randomly chosen and divided into 2 groups named Ketorolac group (Group A) and control group (Group B), 30 cases in each group. 60mg of Ketorolac was given intramuscular 10min after the anesthesia induction to subjects in Group A while subjects in Group B were given 0.9%NS 2ml. The postoperative side-effects such as nausea, vomiting, respiratory depression and the recovery time，extubation time，annoyance level and Visual Analogue Scale（VAS) were observed and compared between the 2 groups. Result The post-operative annoyance level were significantly lower in group A than in group B after extubation by（1.25±0.21）after 15min,(1.18±0.42)after 30min,(1.12±0.36) after 1h and (1.13±0.40) after 2h. The VAS were significantly lower in group A than in group B after extubation by (1.98±0.62)after 15min, (1.94±0.69) after 30min, (1.81±0.65) after 1h, (1.76±0.53)after 2h.The post-operative side-effects were significantly lower in group A than in group B, while there was no statistically significant difference between the 2 groups in the dosage of propofol and extubation time and recovery time (P > 0.05). Conclusion 60 mg of Ketorolac given intramuscular at 15min before the end of surgery can effectively reduce postoperative annoyance in bilateral endoscopic thoracic sympathectomy, and does not affect the extubation time and recovery time. This clinical application is safe and effective, hence is worth promoting.