Ｏｂｊｅｃｔｉｖｅ　To assess the efficacy and safety of oxycodone injection in combination with propofol administered in painless induced abortion.　Methods　Based on random number tables, sixty patients were randomly divided into three groups(n=20): propofol and oxycodone group (group A), propofol and sufentanil group(group B), and propofol and placebo group (group C). MAP, HR, and SpO2 were recorded before anesthesia induction(T1), upon cervical dilatation(T2), and upon recovery time(T3). They also participated in the comparisons of perioperative side effects, VAS T3, thirty minutes after recovery(T4) and three and half hours after recover(T5), administered times of atropine and metaraminol, as well as the discharge time.　Results　Disparities in medical records and operative procedure time of the three groups had no statistical significance(P>0.05). In group A and B, the dose of propofol, (130±22) mg and (141±27) mg respectively, and recovery time, (1.2±0.8) min and (1.3±1.1) min respectively, showed marked decrease compared with group C, whose measurement of the two aspects stood at (164±40) mg and (2.6.±1.6) min(P<0.01). In group A, MAP and HR were measured at (88±8) mmHg(1 mmHg=0.133 kPa) and (78±12) bpm at T1, (77±10) mmHg and (67±8) bpm at T2, showing significant decrease(P<0.01). While in group C, HR registered an increase from(74±7) bpm at T1 to(80±15) bpm at T2(P<0.05). In terms of the rate of body dynamic response, group A and B showed considerable decrease compared with group C(P<0.01). Patients of group A and B suffered noticeably more dizziness than their group C counterparts(P<0.01), with group A faring better than group B (P<0.05). At T3, T4 and T5, group A's VAS were much lower than that of group C(P<0.01). The same thing happened at group B's T3 and T4 when its VAS scored significantly less than that of group C(P<0.01). At T3 and T5, group A's VAS were lower than that of group B(P<0.05), the gap of which was even wider at T5(P<0.01). Disparities in the times of medication administration of the three groups bore no statistical significance(P>0.05). Group C patients stayed longer in hospital than that of group A and B(P<0.05).　Conclusions　Among the three pain management methods, propofol combined with oxycodone, propofol in conjunction with sufentanil and independent dosing of propofol, the first regimen achieved the best efficacy along with fewer side effects, making it a safe and effective option for painless induced abortion.