【Abstract】Objective Effects of autologous blood withdrawal-reinfusion on perioperative Blood protection in patients undergoing cardiac surgery.Methods We electronically searched Cochrane library,Pubmed,EMbase,CINAHL,Web of Science,CBM，CNKI.Randomized controlled trials (RCTs) were indentified about autologous blood withdrawal-reinfusion on perioperative Blood protection. Study selection and meta-analysis were conducted which according to the Cochrane Handbook for systematic reviews. Date were extracted from these trials by 3 reviewers independently and analyzed by RevMan5.1 software. Results The results showed that the application of blood collection equipment can reduce the use of red blood cells in the perioperative period. CI [RR=0.68,95% (0.53, 0.87). The use of blood recycling equipment to reduce the use of fresh frozen plasma. CI [RR=1.53,95% (1.02, 2.31)]. There was no significant difference in the use of the blood group in the treatment group compared with the treatment group. CI [RR=0.86,95% (0.56, 1.32)], there was no difference in the incidence of postoperative complications in the patients with the use of blood recovery equipment. CI [RR=1.14,95% (0.92, 1.41)]. Conclusions the current evidence suggests that the use of autologous blood recovery device in cardiac surgery can reduce the transfusion of allogeneic blood products or red blood cells, which has a very good effect. In addition, autologous blood collection does not increase the incidence of postoperative complications such as bleeding, infection, renal failure and cognitive dysfunction.