国际麻醉学与复苏杂志   2016, Issue (8): 1-1
    
硬膜外局部麻醉药物中添加去氧肾上腺素对老年患者血流动力学影响的初步研究
赵磊, 王天龙, 肖玮, 郎宇1()
1.首都医科大学宣武医院麻醉科
A pilot study of the hemodynamic effects of phenylephrine in epidural local anesthetics in elderly patients
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摘要:

目的 观察硬膜外局部麻醉药物中添加去氧肾上腺素对老年患者血流动力学的影响。 方法 选择30例ASA分级Ⅰ、Ⅱ级,择期硬膜外麻醉下进行全髋或半髋关节置换术的老年患者,按随机数字表法分为对照组和观察组(每组15例)。对照组硬膜外局部麻醉药为利多卡因(2%利多卡因17 ml+生理盐水3 ml,不添加血管活性药物),观察组硬膜外局部麻醉药为添加15 mg/L去氧肾上腺素的利多卡因(2%利多卡因17 ml+100 mg/L去氧肾上腺素3 ml)。记录硬膜外给药前1 min(T0)和麻醉后5 min(T1)、15 min(T2)、30 min(T3)、60 min(T4)及术毕时刻(T5)的HR、SBP、DBP、MAP、心排血量指数(cardiac output index, CI)和每搏指数(stroke volume index, SVI)。记录术中麻黄碱用量。 结果 观察组患者麻醉期间麻黄素用量明显低于对照组[(1.5±3.2) mg比(6.4±8.6) mg](P<0.05),观察组患者T3、T4和T5时的心脏 SVI明显高于T0[分别为(35±8)、(36±9)、(36±9) ml/m2 比(31±8) ml/m2](P<0.05)。 结论 老年患者硬膜外局部麻醉药物中添加少量去氧肾上腺素可减少硬膜外麻醉后麻黄素的用量,并可以增加心脏SVI。

关键词: 硬膜外麻醉; 去氧肾上腺素; 局部麻醉药; 老年患者; 每搏指数
Abstract:

Objective To clarify the hemodynamic effects of phenylephrine added to local anesthetic during epidural analgesia in elderly patients. Methods Thirty elderly(65 y) patients who underwent elective total hip arthroplasty or semi?蛳hip arthroplasty under epidural anesthesia were randomly divided into the control and observation group(n=15). Patients in the control group received lidocaine (2% lidocaine 17 ml + normal saline 3 ml), whereas those in the observation group received lidocaine plus phenylephrine (2% lidocaine 17 ml + 0.1% phenylephrine 3 ml) for epidural anesthesia. The hemodynamic parameters including heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, cardiac output index(CI), and stroke volume index (SVI) were recorded at 1 min(T0) before and 5 min(T1), 15 min(T2), 30 min(T3) and 60 min(T4) after epidural injection and at the end of surgery(T5). The doses of ephedrine were recorded. Results The mean dose of ephedrine used during anesthesia was significantly lower in the observation group than in the control group [(1.5±3.2) mg vs (6.4±8.6) mg](P<0.05). When compared with T0, the SVI was significantly higher at T3, T4 and T5 in the observation group [(35±8), (36±9), (36±9) ml/m2 vs (31±8) ml/m2](P<0.05). Conclusions Phenylephrine, when mixed with local anesthetics, can decrease the requirement of ephedrine and increase the SVI during epidural anesthesia in elderly patients.

Key words: Epidural anesthesia; Phenylephrine; Local anesthesia; Elder patients; Stroke volume index