Ｏｂｊｅｃｔｉｖｅ　To explore the effects of pachyman on postoperative cognitive dysfunction(POCD) in mice with hepatolobectomy.　Methods　Tirty SD aged mices were randomly divided into sham-operated group, model control group and pachyman group by random number table(n=10), to establish hepatolobectomy triggering postoperative cognitive dysfunction model in mices. Postoperative cognitive dysfunction was evaluated by Morris water maze, and enzyme-linked immunosorbent method was used to measure the content of TNF-α and IL-6 in serum.　Results　At the 1, 3, 7 day after surgery, compared with model control group, the time spent in target quadrant with the previously located hidden platform was relatively deacrease and the number of platform-site crossovers was relatively increased. The serum levels of TNF-α and IL-6 in three groups were (18.9±3.9) ng/L and (14.7±3.8) ng/L, (8.9±2.2) ng/L and (9.9±2.6) ng/L, (6.6±1.8) ng/L and (9.6±2.7) ng/L respectively (P<0.05). The spleen coefficient and thymus coefficient in pachyman group were (2.59±0.92) mg/g and (1.60±0.40) mg/g(P<0.05).　Conclusions　Pachyman can improve the symptoms of POCD in mice with hepatolobectomy, and the mechanisms may be inhibit inflammatory reaction and improve immunity.