Objective: The objective of this retrospective study is to investigate the relationship between the postoperative cerebral ischemia and significant changes in SSEP and MEP monitoring, during carotid endarterectomy. Methods: Eighty-four patients undergoing CEA using general anesthesia with monitoring of bilateral SSEP and MEP were retrospectively reviewed between September 2011 and July 2014. The rates of successful assessment of SSEP and MEP and changes in SSEP and MEP monitoring were investigated. Postoperative cerebral ischemia assessed by CT and the correlation between the significant changes of intraoperative evoked potential and postoperative neurological dysfunction was studied. Results: Multimodal SSEP monitoring was achieved in 81 patients, whereas MEP was recorded in 68 cases. Significant SSEP changes occurred in 11 patients and MEP in 29 patients. Five patients showed permanent postoperative neurological deficit. Significant SSEP changes were related with postoperative neurological dysfunction (P <0.05). However, the changes of contralateral MEP were not related with neurological dysfunction without statistically significant (P >0.05). Conclusions: Our data suggest that SSEP were significantly associated with postoperative cerebral ischemia. However, the small number of patients limits the conclusiveness of these findings. MEP monitoring could not prevent a postoperative motor deficit in all patients.