Background　Cleft lip and palate occupy a high proportion in congenital diseases. Pain of cleft lip and palate repair surgery greatly influences feeding and wound healing during perioperation.　Content　This article present the effect of maxillofacial nerve block in cleft lip and palate repair surgery on perioperative analgesia, postoperative revival, relevant complications and postoperative analgesic.　Objective　By summarizing the studies of maxillofacial nerve block, discussing the positive effect and side effect of maxillofacial nerve blocking used for cleft lip and palate repair surgery, this review presents the effective proof of analgesia for cleft lip and palate repair surgery.　Trend　Maxillofacial nerve block is a relatively ideal way for cleft lip and palate repair surgery, especially after ultrasonic introduced, that the related complications was falling. At present, it is still lack of an absolutely satisfying and safe way for maxillofacial nerve block. So the related contents still need further clinical study.