Objective To evaluate the influence of different concentrations of propofol on ischemia-reperfusion replantation surgery prognosis of patients. Methods Chose 100 patients that had done replantation surgery. All patients satisfied the surgery rules through the American Society of Anesthesiologists (ASA) grade Ⅰ ~ Ⅱ grade. Divided 90 patients into three groups randomly, 30cases in each group. Low concentration of propofol was used in group 1(group L), high concentrations of propofol was used in group2(group H) and group 3 is comparative group(group C). All patients in all coracoid single point method brachial plexus, nerve stimulator to locate. Limb were compared in plasma malondialdehyde (MDA), ischemia modified albumin (IMA), concentration of superoxide dismutase (SOD) three indicators. Patients were followed up for a week after surgery were compared the incidence of vascular crisis and survival. Analyzed and summarized the prognosis of different concentrations of propofol anesthesia. Results One hour after anesthesia after tourniquet , the concentration of IMA and MDA in group H and group L were both significantly lower than group C, compare with a significant difference (P <0.05), SOD value in Group H after 1h and L group was significantly lower (P <0.05). After a week of follow-up found that the incidence of vascular crisis in H group and group L were significantly lower than group C, compare with a significant difference(χ(LC)= 4.523，P(LC)=0.033；χ(HC)=9.871，P(HC)=0.005).The survival rate in group H and group L were both significantly higher than finger group C, compare with a significant difference(χ(LC)=3.857，P(LC)=0.049；χ(HC)=6.857，P(HC)=0.009). Conclusion: The propofol can reduce ischemia in patients with limb tourniquet-induced reperfusion injury, improve the body's tolerance to ischemia and hypoxia, the body has a good protective effect. The higher the concentration was used the effect was better.