Abstract: Background Interneurons in the superficial laminae of the spinal dorsal horn, primary afferent fibers, projection neurons in the superficial laminae, descending projection fibers from the upper brain structure and other types of interneurons can form complex local loops, which play important roles in the conduction and regulation of sensory information such as pain, touch and itch. Objective To explore the role of interneurons in the superficial laminae of the spinal dorsal horn on the mechanism of pruritus and new targets for the treatment of pruritus. Content Interneurons in the superficial laminae of the spinal dorsal horn plays key roles in the studies of "mechanical itch" and "chemical itch". Trend Further research on the mechanism of pruritus can provide strong theoretical support for the treatment of pruritus.
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