Abstract: Objective In this study, Meta-analysis was performed to systematically evaluate effects of dexmedetomidine (Dex) on responses to endotracheal extubation and recovery time after general anesthesia in patients with hypertension. Methods Randomized controlled trial (RCT) about the influence of Dex on endotracheal extubation and recovery quality after general anesthesia in patients with hypertension were collected by searching WanFang Data, CNKI, VIP, Pubmed, Embase, and Cochrane library. RevMan 5.3 was used for Meta-analysis. Results A total of 1 280 patients in 16 RCTs were included. In patients subjected to pelvic and abdominal surgery or other surgeries, Dex reduced cardiovascular response to tracheal extubation: decreasing MAP and HR by about 10%-20%; did not prolong recovery time and extubation time; but, reduced postoperative agitation and bucking. There was no significant difference in nausea and vomiting. Conclusions In patients subjected to surgeries, Dex significantly attenuated the cardiovascular responses to tracheal extubation after general anesthesia, and effectively improve recovery from anesthesia.
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