Background The goal-directed fluid therapy is an approach focused on the use of dynamic parameters as end-points for fluids and drugs to optimize individualized fluid therapy, while this therapy is rarely used in neurosurgery, especially intracranial tumor resection. Objective To review the current progress of goal-directed fluid therapy on prognosis in patients undergoing intracranial tumor resection. Content This paper elucidated the effects of different types of fluid and fluid therapy on prognosis in patients undergoing intracranial tumor resection. Trend Whether intraoperative fluid therapy based on goal-directed protocol has distinctive effects on prognosis in patients undergoing intracranial tumor resection is unclear.