Abstract: Background The proportion of obese patient in the surgery gradually rise.Obesity can cause cardiovascular diseases ,and aggravate ventilat-or induced lung injury .Purpose The review highlights the advance in the reason and the mechanism of the pulmonary vascular endothelial injury aggravated by obesity .Content obese patient can cause vascular endothelial injury factors,adipokines such as IL-6,TNF-ɑ and leptin .ALL of these,and several physiological functions,can aggravate the pulmonary vascular endothelial injury caused by mechanical ventilation . Trend Individualized ventilation management will help us to reduce postoperative complications of respiratory system of obese patients.
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