国际麻醉学与复苏杂志   2018, Issue (3): 0-0
    
肥胖加重机械肺通气引起的肺血管内皮损伤的研究进展
高婷婷, 江来1()
1.上海交通大学附属新华医院
Advances in study that obesity aggravate the pulmonary vascular endothelial injury caused by mechanical ventilation
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摘要:

背景 肥胖患者在手术人群中所占的比例逐年上升。肥胖不仅可以导致不可逆的心血管疾病,而且可以加重围手术期麻醉过程中产生的呼吸机相关肺损伤。目的 对肥胖加重机械通气引起的肺血管内皮损伤的原因和机制进行综述。内容 肥胖患者通过自身介导的细胞因子、分泌的脂肪因子(IL-6、TNF-ɑ、瘦素)以及本身的生理功能加重机械通气引起的肺血管内皮损伤。趋向 通过加强个体化的麻醉管理减轻肥胖患者的术后呼吸系统并发症。

关键词: 肥胖;肺血管内皮损伤;机械肺通气
Abstract:

Background The proportion of obese patient in the surgery gradually rise.Obesity can cause cardiovascular diseases ,and aggravate ventilat-or induced lung injury .Purpose The review highlights the advance in the reason and the mechanism of the pulmonary vascular endothelial injury aggravated by obesity .Content obese patient can cause vascular endothelial injury factors,adipokines such as IL-6,TNF-ɑ and leptin .ALL of these,and several physiological functions,can aggravate the pulmonary vascular endothelial injury caused by mechanical ventilation . Trend Individualized ventilation management will help us to reduce postoperative complications of respiratory system of obese patients.

Key words: obesity; pulmonary vascular endothelial injury; ventilator induced lung injury