一氧化氮（nitric oxide, NO）作为体内重要的气体信号分子，对缺血/再灌注（ischemia/reperfusion, I/R）心脏具有重要的保护作用。NO通过环磷酸鸟苷酸（cyclic guanosine monophosphate, cGMP）依赖的蛋白激酶（cGMP-dependent protein kinase, PKG）以及蛋白质巯基（-SH）亚硝基化（S-亚硝基化）在心脏I/R过程中发挥保护作用。文章综述体内NO的合成及其在心脏I/R过程中的作用、NO的心脏保护机制、NO在临床心脏保护中的应用。为NO的心脏保护作用的进一步研究提供参考。
As an essential gaseous signal molecule, nitric oxide (NO) has an important role in cardioprotection after ischemia/reperfusion (I/R). To provide insights for further study of NO in cardioprotection, this article reviewed the research progress on NO synthesis, its role in cardiac I/R injury, cardioprotective mechanisms, and its clinical application. The cardioprotective effects of NO in cardiac I/R may produce via the cyclic guanosine monophosphate(cGMP)/cGMP-dependent protein kinase(PKG) signaling pathway and protein S-nitrosylation. The commonly used cardioprotective measures and drugs are dependent on NO to various extents.
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