Ｏｂｊｅｃｔｉｖｅ　Using analgesia pump to rabbit after combined spinal- epidural anethesia(CSEA), then observing injury to spinal cord which is induced by ropivacaine.　Methods　Thirty six white rabbits of either sex weighing 2.0-2.5 kg were randomly divided into three groups (n=12): group A, EA (epidural anesthesia); group B, CSEA; group C, CSEA (NS). Each group is killed at 2 d and 7 d. All rabbits are monitored hemodynamic parameters by monitor and cathetered in L6-L7. Group A connect analgesia pump (0.2% ropivacaine 20 ml), group B puncturing subarachnoid, then connect analgesia pump (0.2% ropivacaine 20 ml) too, group C puncturing subarachnoid, then connect analgesia pump (NS 100 ml). Assessing and recording the degree of motor block at 2 d and 7 d. Resectting the lumbar segments of spinal cord for histologic examination, observation of apoptosis and expression of Bcl-2.　Results　Compared with anatomical control, structure of the spinal cords are normal. Injury caused by oppression and penetration can not be observed in group C. Compared with positive control.no significant differences in the activity of hind legs in group A, group B and group C. Apoptotic index and Bcl-2 expression levels in each groups had no significant differences too (P>0.05).　Conclusions　Point two percent ropivacaine in analgesia pump would not cause injury on spinal cord and affect the activity of the hind limbs. NS in analgesia pump would not cause injury through oppression and penetration. 0.2% ropivacaine in analgesia pump can not affect hemodynamic parameters of rabbit.