Mitophagy mainly refers to a process where depolarization damage occurs in the intracellular mitochondria under the stimulation of nutritional deficiencies, cell aging and reactive oxygen species (ROS), and then damaged mitochondria are specifically wrapped into the autophagosome before fusion with lysosomes, and complete their degradation to maintain intracellular homeostasis. Abnomral mitophagy is closely related to the development of neurodegenerative diseases such as Alzheimer′s disease (AD). The current article summarizes the latest research progress in the roles of mitophagy in the pathogenesis of AD and drug intervention studies. The article illustrates that mitophagy can provide new theoretical evidence for the in-depth study of AD treatment strategies in the future.