国际麻醉学与复苏杂志   2018, Issue (4): 0-0
    
重度子痫前期产妇剖宫产蛛网膜下腔阻滞所需罗哌卡因ED50和ED95的研究
沈洁, 颜洁, 沈晓凤1()
1.南京医科大学附属妇产医院麻醉科
To study the ED50 and ED95 of intrathecal ropivacaine for severe preeclamptic patients undergoing cesarean section.
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摘要:

目的:研究重度子痫前期产妇行剖宫产时蛛网膜下腔使用的罗哌卡因的ED50和ED95。 方法:300名行择期剖宫产重度子痫前期的产妇随机双盲的分为5组,分别鞘内注射7.5mg、10mg、12.5mg、15mg、17.5mg的0.5%重比重罗哌卡因。麻醉效果不好者硬膜外追加罗哌卡因。根据结果计算罗哌卡因的ED50和ED95。记录罗哌卡因、去氧肾上腺素的用量和患者满意度。观察各组术中并发症以及新生儿的Apgar评分。 结果:有效的蛛网膜下腔罗哌卡因剂量的ED50和ED95分别为9.3mg(95%的可信区间[CI]为:8.6-9.9mg)和14.9mg(95%CI为:13.7-16.9mg)。各组间的10分钟后阻滞平面明显不同(P<0.05)。15mg、17.5mg组的低血压发生率明显高于其他组(P<0.05)。15mg组、17.5mg组去氧肾上腺素的用量高于其他两组,差异均有统计学意义(P<0.05)。7.5mg和10mg组追加的罗哌卡因的量明显高于15mg和17.5mg组(P<0.05)。各组间其他不良反应、患者满意度和新生儿的Apgar评分差异无统计学意义(P<0.05)。 结论:重度子痫前期产妇行腰硬联合麻醉时罗哌卡因的ED50和ED95为:9.3mg和14.9mg。

关键词: 罗哌卡因,剖宫产,重度子痫前期,蛛网膜下腔阻滞
Abstract:

Objective: To study the ED50 and ED95 of intrathecal ropivacaine for severe preeclamptic patients undergoing cesarean section. Method: The study population comprised 300 severe preeclamptic patients undergoing elective cesarean section. They were randomized, double-blinded into 6 equal groups who received 7.5mg,10mg,12.5mg,15mg and 17.5mg. Additional epidural analgesia was an epidural injection of 5ml of 0.75% ropivacaine if the spinal anesthesia was failure. The use of ropivacaine and phenylephrine and the patients’ satisfaction was recorded. Intraoperative compIications and the newborns’ Apgar score were documented. Results: ED50 and ED95 of intrathecal ropivacaine for successful spinal anesthesia were 9.3 mg (95% confidence interval [CI]: 8.6-9.9mg) and 14.9mg (95% CI: 13.7-16.9mg) respectively. The sensory block was significantly different among groups 10 minutes after intrathecal injection(P < 0.05). The incidence of hypotension in Group 17.5 mg and Group 15 mg was higher than that in Group 7.5 mg and Group10 mg (P < 0.05). The use of phenyIephrine in groups 15mg and 17.5mg was higher than that in other two groups(P < 0.05). The use of ropivacaine in group 7.5mg and 10mg was higher than that in other groups(P < 0.05). There was no significant difference in patients’ satisfaction, the Apgar score of newborns (P>O.05)among four groups. Conclusion: Our study showed that the ED50 and ED95 of intrathecal ropivacaine for severely preeclamptic patients undergoing elective cesarean delivery were 9.3 mg and 14.9 mg, respectively.

Key words: ropivacaine, cesarean section, severe preeclampsia, spinal anesthesia