【Abstract】 Objective To investigate the effect of preload different kinds of liquid combined with phenylephrine on Parturients and neonate during epidural anesthesia for cesarean section. Methods Sixty patients who were eligible to cesarean section were randomly divided into two groups: hydroxyethyl starch (6% in normal saline )500 ml (group H) and Lactated Ringer’s solution 1000 ml (group R), 30 cases in each group. All patients were treated with a phenylephrine infusion 0.5 μg·kg-1·min-1.Phenylephrine infusion protocol was continued until the time of fetal extraction. Recorded the anesthesia (T0), 3 min (T1), 10 min (T2), delivery the fetus of 3 min (T3)、10 min (T4) the HR, SBP and DBP before and after cesarean section; The maternal perioperative adverse events of parturients and the Apgar score of the newborn at 1, 5 min were recorded. Detection of fetal delivery when the umbilical vein blood gas. At the same time, umbilical vein blood gas analysis results of the fetus after delivery was also recorded. Results compared with group R, group H at T4 HR was significantly decreased, compared with group H, group R at T2 SBP decreased significantly (P<0.05). HR in group H decreased T1,T2,T4 but not in grop R, SBP in grop H decreased T1,T2 and grop R decreased T2,T4. DBP in grop H decreased T1～T4 and grop R decreased T2～T4.Group R of fetal umbilical venous blood lactate was significantly higher than H group (P<0.05), group H of fetal umbilical vein blood glucose was higher than that of R group (P<0.05); no significant Apgar score difference between the two groups in 1 min and 5 min, nausea and vomiting, dizziness, chest tightness, there was no significant difference between the two groups (P>0.05).Conclusions The preload with 6% of hydroxyethyl starch before cesarean section was beneficial for the more stable hemodynamics, and has less effect on infant outcomes.