胆碱能抗炎通路（cholinergic anti-inflammatory pathway, CAP）是一条神经免疫调节通路，可以控制机体炎症的发生、发展，对急性肺损伤（acute lung injury, ALI）/急性呼吸窘迫综合征（acute respiratory distress syndrome, ARDS）的基本病理特征之一的过度炎症反应也发挥关键的调节作用。文章从CAP的内涵、其传出通路中参与调节ALI/ARDS病理过程的细胞和分子方面进行综述。为寻找ALI/ARDS的新型治疗方式提供新思路。
The cholinergic anti-inflammatory pathway (CAP) is a pathway that nerve system controls the innate immunity. This pathway plays a critical role in controlling the systematic inflammation. Moreover, this pathway regulates over immune-reaction to the inflammation after acute lung injury/acute respiratory distress syndrome (ALI/ARDS). The review summarized the connotation of the cholinergic anti-inflammatory pathway, their contribution in modulation of ALI/ARDS, such as the new concept-pulmonary parasympathetic inflammatory reflex, as well as cells and molecules which are involved in this process. Considering the perspective of cholinergic anti-inflammatory pathway, we may find new ways for ALI/ARDS treatment.
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