国际麻醉学与复苏杂志   2020, Issue (1): 0-0
    
双孔背景钾通道TREK‑1参与麻醉相关作用研究进展
赵帅, 欧阳晔凌, 胡志强, 陈向东, 姚尚龙1()
1.华中科技大学同济医学院附属协和医院
The involvement of two‑pore domain K+ channel TREK‑1 in anesthesia
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摘要：

TREK‑1是双孔背景钾通道（tow‑pore domain K+ channel, K2P）成员之一，参与调控细胞静息膜电位等，有着多种功能特性。近年来研究表明，TREK‑1在麻醉、疼痛、神经保护和抑郁方面有着极其重要的作用。文章综合国内外TREK‑1相关文献，简要概述TREK‑1结构、功能、分布和调控，重点介绍TREK‑1在上述领域的研究进展。通过进一步阐述TREK‑1在麻醉、疼痛、神经保护和抑郁领域的作用，可以更好地认识TREK‑1在其中的病理意义，并有助于新药物的开发。
关键词： TREK‑1； 双孔背景钾通道； 麻醉； 疼痛； 神经保护； 抑郁
Abstract:

TREK‑1, a member of two‑pore domain K+ channel (K2P) family, has various functions and participates in the regulation of resting membrane potentials. Recent studies indicate that TREK‑1 is essential in anesthesia, pain, neuroprotection and depression. Based on domestic and foreign literature related to TREK‑1, this review concisely outlines the structure, function, distribution and modulation of TREK‑1, and thoroughly presents the advances in those fields above. Furthermore, the role of TREK‑1 in general anesthesia, pain, neuroprotection and depression has been elaborated, so as to provide better understanding of the pathological implication of TREK‑1 in these fields and facilitate the development of new drugs.
Key words: TREK‑1; Tow‑pore domain K+ channel; Anesthesia; Pain perception; Neuroprotection; Depression