Now, I-gel Laryngeal mask is widely used in clinical anesthesia. In this paper, we will discuss the clinical value of I-gel laryngeal mask application in hip surgery, laparoscopic kidney surgery, thoracoscopic surgery and spinal surgery with lateral and prone position. Although the efficacy and safety of I-gel laryngeal mask in surgery with lateral and prone positions have been confirmed to some extent, how to manage airway more reasonably for elderly patients undergoing non-intubated general anesthesia with autonomous respiration in lateral position still needs further study.