Maternal fever in labor is a complication with complicated mechanisms, and plays an important role in delivery outcome and infant prognosis. A great number of clinical studies have found the relationship between epidural analgesia and maternal fever in labor. Recent researches show that the possibility of the non‑infectious mechanism of epidural‑related maternal fever (ERMF). This review is designed to introduce the research progress in ERMF‑related inflammatory mechanism through summarizing the current findings regarding the physical changes of pregnancy and labor, systemic and local inflammation, epidural analgesia and triggers of inflammation. A better understanding of ERMF mechanism is helpful to improve the clinical diagnosis and treatment of maternal fever in labor and allow a better outcome of both mothers and babies.