Idiopathic trigeminal neuralgia is called "the worst pain in the world", with unknown etiology and pathogenesis. Minimally invasive interventional therapy is simple and effective, and suitable for most patients. The current study is to review the commonly used minimally invasive interventional techniques in recent years, so as to provide reference for clinical selection. The mechanism and clinical efficacy of drugs, surgical treatment, radiofrequency thermocoagulation, pulse radiofrequency, balloon compression, and chemical drug injection (anhydrous alcohol, glycerin, adriamycin, botulinum toxin) were introduced. Drugs are the basis for the treatment of trigeminal neuralgia. All kinds of minimally invasive interventional techniques for refractory trigeminal neuralgia are generally safe and effective, but each has its own strengths and weaknesses.