Abstract: Objective To observe the effects of ultrasound-mediated drug delivery of Dachengqi decoction through Tianshu (ST25) point on the early recovery quality of patients after radical gastrectomy. Methods A total of one hundred and twenty patients who received radical gastrectomy were randomly divided into a control group (group C) and an ultrasound transdermal delivery group (group U) (n=60). The patients in the two groups underwent conventional endotracheal intubation anesthesia, anesthesia induction and maintenance. Group C received routine treatment and nursing after operation, while group U was delivered with Dachengqi decoction through bilateral Tianshu(ST25) point (two inches apart from the umbilicus) under the mediation of ultrasound, 30 min/times and twice/day. After treatment, traditional Chinese medicine patches was retained for 30 min. According to the patients′ gastrointestinal function recovery, the total treatment duration and times were determined until anus exhaust and defecation. The time of bowel sound onset, anus exhaust time, and defecation time were recorded. The levels of plasma motilin (MTL) and serum gastrin (GAS) were measured at 1 day(T0) before operation, 24 h(T1), 48 h(T2), and 72 h(T3) after operation. The quality of recovery was assessed by Quality of Recovry?蛳40(QoR?蛳40) on T0 to T3. Results Group C showed remarkably longer bowel sounds appear time, anus exhaust time, and defecation time than group U(P<0.05). The contents of MTL and GAS in the two groups were significantly reduced at T1 and T2 compared with those at T0 (P<0.05), but the contents of MTL and GAS in group U were higher than those in group C(P<0.05). The emotional state, physical comfort, psychological support, self?蛳care ability, pain scores and the total scores of QoR-40 was remarkably reduced for group U at T1 and for group C at T1 and T2 in group C, compared with those at T0 (P<0.05). Group U demonstrated significantly improved emotional state, physical comfort, psychological support, self-care ability, pain scores and the total scores of QoR-40 in comparison with group C at T1 and T2(P<0.05). Conclusions Ultrasound-mediated drug delivery of Dachengqi decoction through Tianshu(ST25) point can promote the recovery of gastrointestinal function in patients after radical gastrectomy and improve the quality of early recovery.
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