Pain experience is an unpleasant feeling and emotional experience that troubles people. In recent years, it has been reported that TRPA1 (Transient receptor potential cation channel,subfamily A,member 1) channel which is one of the TRPs (transient receptor potential cationic channel family) member is involved in different types of pain pathogenesis caused by temperature, chemical and mechanical stimulis. In this paper, we explored the mechanism of TRPA1 involved in pain, and reviewed the current research progress of TRPA1 in pain treatment, and provided reference for the development of new analgesic drugs.