右美托咪定（dexmedetomidine, Dex）具有诸多优势，现已广泛运用于临床麻醉、ICU中重症患者的镇静治疗，但其产生镇静催眠的作用机制至今尚未完全阐明。文章探讨了Dex产生镇静催眠作用的分子受体靶点、参与作用的功能核团及镇静时对脑电活动、脑代谢影响的研究进展。阐明Dex产生镇静催眠的作用机制，对揭示全身麻醉机制、提高临床麻醉安全性以及开发更为有效的镇静催眠类药物具有重要指导意义。
α2 adrenergic agonist dexmedetomidine (Dex) is widely used in the sedation of clinical anesthesia and intensive care unit because of its abundantly advantages. However, until now the exact mechanism of sleep and sedative effects induced by Dex is not entirely understood. This review aims to summarize the molecular target of Dex, possible nucleus and circuits which related to its sleep and sedative effects and its effect on polysomnography and cerebral metabolism. To review the original nuclei and neuronal circuit of the sedative and hypnotic effects induced by Dex own great clinical significance in exploring the mechanism of general anesthesia, improving the safety of clinical anesthesia and developing more effective sedative and hypnotic drugs.
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