Objective: To evaluate the effect of blood salvage for puerpera underwent cesarean section with placenta previa. Methods: To review the puerpera who underwent cesarean section in our hospital from January 2017 to January 2019 and were clearly diagnosed as placenta previa by ultrasound or MRI. The intervention group (group I) and control group (group C) are divided depending on whether using blood salvage or not, with 40 cases in group I and 41 cases in group C. The puerpera in group I received automatic washing autologous blood salvage; Group C did not use blood salvage and allogeneic blood was transfused if blood transfusion indications were met. Preoperative data including age, blood routine and coagulation related indexes were reviewed. Intraoperative blood loss, transfusion of allogeneic blood products and other postoperative data such as postoperative blood loss, incidence of postpartum hemorrhage were reviewed. Results: There was no statistically significant difference in the amount of intraoperative bleeding between the two groups (P0.05). The average amount of autologous blood transfusion in group I was (350.1±88.3) mL . There were 16 and 35 patients in group I and C receiving allogeneic RBC infusion, respectively. The infusion rate and volume of allogeneic RBC infusion in group I was significantly lower than that in group C, with statistically significant differences (P0.05). There was no significant difference in FFP infusion rate and infusion volume between the two groups (P0.05). Hb, RBC and PLT were significantly decreased, while PT, APTT, FIB and TT were significantly increased after operation (P0.05). There was no significant difference in Hb, RBC, PLT, PT, APTT, FIB and TT between the two groups (P0.05). There were no statistically significant differences in postpartum blood loss, PPH, incision infection, and incidence of pelvic hematoma between the two groups (P0.05). Conclusion: For puerpera undergoing cesarean section with placenta previa, blood salvage can significantly reduce the rate of allogeneic blood transfusion and allogeneic blood transfusion volume during the operation, and does not increase the risk of adverse events after the operation, but significantly increase the related costs of blood transfusion.