Objective To investigate the correlation between EV1000 hemodynamic parameters and hospitalization outcome in patients with traumatic brain injury (TBI) and to discuss the intraoperative characteristics of hemodynamic changes and evaluate the clinical significance of EV1000 hemodynamic monitoring in TBI patients. Methods A retrospective analysis was performed on 35 TBI patients undergoing craniotomy for hematoma evacuation under general anesthesia from February 2018 to December 2019 in Beijing Tiantan Hospital. According to the hemodynamic parameters before and after removal of the bone flap (they are represented by 0 and 1 respectively, and 0 and 1 are placed behind the corresponding hemodynamic parameters to distinguish them), the patients were divided into the following groups: a low mean arterial pressure (MAP) group and a normal MAP group, a high heart rate (HR) group and a normal HR group, a low cardiac index (CI) group and a normal CI group, a low stroke volume index (SVI) group and a normal SVI group, a low systemic vascular resistance index (SVRI) group and a normal SVRI group. The differences in Glasgow Coma Scale (GCS) scores on admission and discharge were analyzed among these groups. Univariate regression analysis was used to determine the correlation between these hemodynamic parameters and GCS on admission and discharge. Results Before removal of the bone flap, there were no statistical differences in age, gender or GCS on admission among the different groups (P>0.05). There were no statistical differences in GCS on discharge between the low MAP0 and normal MAP0 groups, the low CI0 and normal CI0 groups, the low SVRI0 and normal SVRI0 groups (P>0.05). The GCS on discharge in the high HR0 group was lower than that in the normal HR0 group (P<0.05), and the GCS on discharge in the low SVI0 group was lower than that in the normal SVI0 group (P<0.05). After removal of the bone flap, there were no statistical differences in age and gender among the different groups (P>0.05). There were no statistical differences in GCS on admission between the low MAP1 and normal MAP1 groups, the high HR1 and normal HR1 groups, and the low SVRI1 and normal SVRI1 groups (P>0.05). The GCS on admission and discharge in the low CI1 group were lower than those in the normal CI1 group (P<0.05), The GCS on admission and discharge in the low SVI1 group were lower than those in the normal SVI1 group (P<0.05), and the GCS on discharge in the high HR1 group was lower than that in the normal HR1 group (P<0.05). There were no statistical differences in GCS on discharge between the low MAP1 and normal MAP1 groups, the low SVRI1 and normal SVRI1 groups (P>0.05).After adjustment of gender and age, univariate linear regression analysis showed that there was no correlation between the hemodynamic indexes and GCS on admission before removal of bone flap. The increase in HR and the decrease in SVI were related to low GCS on discharge before removal of the bone flap. The GCS on discharge in the high HR group and the low SVI group were 3.76 and 2.73 points lower than those in the normal group, respectively (P<0.05). After removal of the bone flap, the decrease in SVI was related to low GCS on admission. The GCS on admission in the low SVI group was 3.09 points lower than that in the normal group (P<0.05). The increase in HR, the decrease in CI and the decrease in SVI were related to low GCS on discharge. The GCS on discharge in the high HR group, the low CI group, and the low SVI group were 3.77, 3.14 and 4.52 points lower than those in the normal group, respectively (P<0.05). Conclusions TBI patients present great individual differences in hemodynamic indexes. Intraoperative high HR, low SVI, and low CI after removal of the bone flap are related with hospitalization outcome, which suggests that EV1000 hemodynamic monitoring is necessary for TBI patients.