国际麻醉学与复苏杂志   2021, Issue (4): 0-0
    
不同全身麻醉药物的脑电特征研究进展
康娜, 魏昌伟, 吴安石1()
1.首都医科大学附属北京朝阳医院
Research progress on the electroencephalogram characteristics of different general anesthetics
 全文:
摘要:

脑电图(electroencephalography, EEG)可以探测到神经振荡信息,在全身麻醉过程中,大脑功能和有效的区域间连接、意识网络拓扑结构和区域间相互作用的时空动力学发生了明显的变化。EEG结合功能影像学研究为探索麻醉药物机制提供了一种有效的方法。文章回顾了3种静脉麻醉药[丙泊酚、右美托咪定(dexmedetomidine, Dex)和氯胺酮]和3种吸入麻醉药(七氟醚、异氟醚、地氟醚)的神经药理学机制,分别总结了全身麻醉药物的脑电特征以及相应大脑功能的改变(如连通性下降、复杂度降低和空间网络改变等)。同时,麻醉药物的EEG特征研究对理解大脑觉醒环路的神经生理学机制提供帮助。

关键词: 麻醉药物; 脑电图; 意识; 大脑功能
Abstract:

Electroencephalography (EEG) can detect neural oscillation. During general anesthesia, brain function and effective inter‑regional connections, network topology, and inter‑regional interactions have undergone significant changes in spatiotemporal dynamics. A combined use of EEG and functional imaging examination provides an effective approach to explore the mechanism of anesthetics. This article reviews the neuropharmacological mechanisms of three types of intravenous anesthetics [propofol, dexmedetomidine(Dex) and ketamine] and inhalation anesthetics (sevoflurane, isoflurane, and desflurane). Then, the EEG characteristics of general anesthetics and the corresponding changes in brain function, such as decreased connectivity, reduced complexity and spatial network shifts were summarized. This study will facilitate the understanding of the neurophysiological mechanism involved in the brain arousal loop.

Key words: Anesthetics; Electroencephalography; Consciousness; Brain function