Objective To discuss the sedation and emergency protocol of computer tomography (CT) examination for pediatric patients suspected with infection of SARS‑CoV‑2. Methods According to national COVID‑19 policies and guidelines, we established a sedation protocol, a medication protocol, and a protocol for preparing sedation related materials, a checking protocol, and an emergency protocol, and sedation related personals were trained. Results From February 3 to March 10, 2020, the Sedation and Analgesia Center of Kunming Children's Hospital completed sedation for CT examination of 76 pediatric patients with suspected COVID‑19. The children were (17±5) months, weighing (11.4±1.7) kg. Among them, 74 patients were sedated through intravenous injection of propofol. The induction time was (2.8±1.2) min, the examination time was (5.6±1.6) min and the recovery time was (16.2±2.2) min. Two patients were intranasal administered with dexmedetomidine. All children completed CT examination. Two cases (2.63%) of adverse events were recorded as hypoxemia, 3 cases (3.95%) as vomiting within 2 h after returning to the ward. There were no laryngeal spasm, cardiac arrest and death cases. Conclusions In order to guarantee the safety of sedation for pediatric patients suspected with infection of SARS‑CoV‑2, we should establish proper protocols and lay out functional areas based on national regulations and guidelines, and rationally classify the necessities, and provide medical staff with emergency protocol training under special circumstances, so as to provide safe and comfort medical treatment for children with suspected COVID‑19 during sedation for CT examination.