Circular RNA (circRNA), a class of the latest discovered non‑coding RNA, has become a research hotspot in recent years owing to its special structure and its unique role in regulating disease. CircRNA has been demonstrated to regulate the pathogenesis of heart failure, especially in cardiac remodeling, which is regarded as the central part of heart failure. This article reviews the functions of circRNA and its role in the progression of heart failure, and lists some examples to illustrate its effect on regulating cardiac myocyte pathological development, myocardial interstitial fibrosis, and angiogenesis. In addition, this article illustrates the study advances of circRNA as new biomarkers in heart failure. This article shows the great potential of circRNA for therapeutic targets as well as biomarkers of heart failure and providing a new strategy for future diagnosis and therapy in heart failure.