Objective To investigate the effects of perioperative anesthetic management with enhanced recovery after surgery (ERAS) protocols on humoral immunity function and postoperative recovery in children with abdominal malignant tumors. Methods A total of 70 children, aged 1‑4 years, American Society of Anesthesiologists (ASA) grade Ⅱ‑Ⅲ, who were scheduled for abdominal malignant tumor resection were enrolled. They were divided into two groups (n=35) according to the random number table method: a control group (group C) and an ERAS group (group E). Patients in group E underwent perioperative anesthetic management by ERAS protocols, while traditional methods were adopted in group C. Postoperative analgesic effects were evaluated by Face, Legs, Activity, Cry, and Consolability (FLACC) method and the levels of C‑reactive protein (CRP), interleukin 6 (IL‑6), immunoglobulin A (IgA), immunoglobulin G (IgG), and immunoglobulin M (IgM) were recorded before entry into the room and 24 h, 48 h, and 72 h after operation. Their total dosage of propofol and remifentanil, postoperative adverse reactions and complications, postoperative recovery, the length of hospitalization stay, and total expenses were recorded. Results Sixty‑four patients were finally included, including 34 cases in group C and 30 cases in group E. Compared with the levels before entry into the room, the levels of CRP and IL‑6 in the two groups significantly increased after surgery (P<0.05). Compared with group C, the levels of CRP 72 h after operation and the levels of IL‐6 48 h and 72 h after operation in group E significantly reduced (P<0.05). Compared with the levels before entry into the room, the levels of IgG and IgM in the two groups significantly reduced 24 h, 48 h and 72 h after operation (P<0.05). But the levels of IgG and IgM in group E were significantly higher than those in group C 48 h and 72 h after operation (P<0.05). The total dosages of propofol and remifentanil in group E was significantly less than that those in group C (P<0.05). There was no difference in postoperative analgesia between the two groups at each time point (P>0.05). The incidence of postoperative adverse events and complications in group E was significantly less than that in group C (P<0.05). In terms of postoperative recovery, the first bowel sound time, the first exhaust time and the first time to get off for exercises in group E were significantly earlier than the times in group C (P<0.05), but there was no significant difference in the length of postoperative hospitalization stay and total hospitalization expense between the two groups (P>0.05). Conclusions ERAS protocols can reduce the stress response of children with abdominal malignant tumors, protect the humoral immune function, and promote the postoperative recovery of children to a certain extent.