Innate lymphoid cells (ILCs) are a type of innate immune cells which have attracted increasing attention in recent years. Type Ⅱ innate lymphoid cells (ILC2), as a major cell subpopulation, are involved in mediating multiple pathophysiological processes such as inflammation and tissue repair. During sepsis, the innate immune system is activated, resulting in excessive inflammatory responses and immunosuppression. In this review, we summarize the effects of type Ⅱ immunity on the pathogenesis of sepsis based on recent research at home and abroad. By describing the source of ILC2, activating factors, communication between cells and the latest research progress, we reveal the important role of ILC2 in sepsis.