Frailty denotes a nonspecific clinical condition characterized by a decrease of physiological reservation in multiple organ systems, which makes individuals extremely vulnerable to stressors. Emerging evidences show that frailty is a significant risk factor for adverse outcomes in patients with cirrhosis who experience liver transplantation. On one hand, this review mainly describes assessment methods, clinical implications, advantages and disadvantages of Fried Frailty Phenotype (consisting of weight loss, exhaustion, grip strength, walking speed, and physical activity) and Liver Frailty Index (consisting of grip strength, chair stands, and balance), which are used for patients with cirrhosis awaiting liver transplantation. On the other hand, we present some evidence‑based pre‑rehabilitation methods (including nutritional support, exercise therapy, and drug intervention) before liver transplantation for preventing the frailty of patients with cirrhosis. This review aimed to provide a clinical strategy based on frailty assessment and pre‑rehabilitation program for contributing to preoperative management in liver transplant recipients. Furthermore, this strategy can also improve the prognosis of these patients by improving patients' fitness before surgery.