【Abstract】 Objective To investigate the effects of flurbiprofen axetil combined with dezocine on postoperative hyperalgesia in the nicotine high-dependence patients after laparoscopic surgery. Methods One hundred nicotine high-dependence patients underwent elective laparoscopic cholecystectom , ASA I or II , were randomly divided into 4 groups(n= 25 each): control group(group C) ; flurbiprofen axetil group(group F) ; dezocine group(group D); flurbiprofen axetil plus dezocine group(group DF). Before induction of anesthesia, dezocine 0.2 mg/kg, flurbiprofen axetil 2 mg/kg, and flurbiprofen axetil 1 mg/kg plus dezocine 0.1 mg/kg were injected intravenously in D, F and DF groups respectively, while the equal volume of normal saline was given in group C. Assessment the visual analog score (VAS), Bruggrmarm comfort score (BCS) at postanesthesia care unit (PACU) immediately(T1) .15 min (T2). leave PACU(T3) and postoperative 24h(T4) .The operation time, anesthesia time, wake up time, extubation time, PACU time, using rate of remedial measures and nausea and vomiting were recorded. Results There were no statistical differences operation time, anesthesia time, wake up time, extubation time, PACU time between 4 groups (P＞0.05). The VAS at T1, T2 and T4 in group C was significantly higher than group D,group F, group DF; group C in T3 was higher than groupF and group DF, there were statistical differences (P＜0.05). The VAS in group DF was lower than group D and group F, there were statistical differences (P＜0.05). The BCS was lower in group C than other three group at whole time , there were statistical differences (P＜0.05). The BCS in group DF was higher than group D and group F at T4 , there were statistical differences (P＜0.05). Compare with group C, the drowsiness was highest in group D, the remedial measures were lower in group D, group F and group DF, there were statistical differences (P＜0.05) .Compare with group DF , the drowsiness was higher in group D ,the remedial measures was higher in group F, there were statistical differences (P＜0.05).There was no significant difference in postoperative nausea and vomiting among the four groups. Conclusions The combination of flurbiprofen axetil and dizocine has a better effect on postoperative pain in patients with high nicotine dependence and improves patient comfort and satisfaction.